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Meso Scale Diagnostics LLC
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Twist Bioscience
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Illumina Inc
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Illumina Inc
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Illumina Inc
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Sophia Genetics
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Meso Scale Diagnostics LLC
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KCAS Bioanalytical and Biomarker Services
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Meso Scale Diagnostics LLC
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Illumina Inc
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Merck KGaA
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Meso Scale Diagnostics LLC
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Image Search Results
Journal: Circulation. Cardiovascular genetics
Article Title: Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers
doi: 10.1161/CIRCGENETICS.111.961813
Figure Lengend Snippet: Demographic and clinical characteristics
Article Snippet: Commercial MSD kits (
Techniques: Significance Assay
Journal: Circulation. Cardiovascular genetics
Article Title: Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers
doi: 10.1161/CIRCGENETICS.111.961813
Figure Lengend Snippet: PF4 region SNPs and genetic association with serum PF4 levels
Article Snippet: Commercial MSD kits (
Techniques:
Journal: Circulation. Cardiovascular genetics
Article Title: Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers
doi: 10.1161/CIRCGENETICS.111.961813
Figure Lengend Snippet: Schematic representation and LD pattern of the 4q12-q31 region SNPs. The upper panel shows the location of the PF4, PPBP and CXCL5 genes and neighboring significant SNPs (n=30). In the middle panel, imputation quality of these SNPs is shown as RSq (squared correlation between imputed and true genotypes) and directly genotyped SNPs are marked as 1. (1a) The bottom panel shows LD pattern of these SNPs in African Americans, constructed using Haploview (version 4.1) software (http://www.broad.mit.edu/mpg/haploview/index.php). Numbers within diamonds and degree of shading represents the magnitude of the pair-wise LD (measured as r2, black to white gradient reflecting higher to lower LD values). The observed most significant SNP with serum PF4 levels is highlighted in bold. For Whites, the pair-wise correlation of these SNPs is shown in Figure 1b.
Article Snippet: Commercial MSD kits (
Techniques: Construct, Software
Journal: Circulation. Cardiovascular genetics
Article Title: Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers
doi: 10.1161/CIRCGENETICS.111.961813
Figure Lengend Snippet: Association and conditional analysis of the genotyped and imputed SNPs from the PF4 region
Article Snippet: Commercial MSD kits (
Techniques:
Journal: Circulation. Cardiovascular genetics
Article Title: Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers
doi: 10.1161/CIRCGENETICS.111.961813
Figure Lengend Snippet: Distribution of serum PF4 levels. The histogram displays the mean values of transformed serum PF4 levels stratified by genotype at the rs168449 locus. The 95% confidence interval (CI) around the mean is represented as vertical bars and number above the bars indicate individual counts observed for the respective genotype group.
Article Snippet: Commercial MSD kits (
Techniques: Transformation Assay
Journal: Clinical Epigenetics
Article Title: DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies
doi: 10.1186/s13148-025-01877-1
Figure Lengend Snippet: Age-associated DNAm changes in primary myelofibrosis. a – d The correlation between epigenetic age predictions with chronological age and the difference between predicted and chronological age (delta-age) was determined with epigenetic clocks developed by a,b) Horvath and c,d) Han et al. . Statistical significance was determined using an unpaired t -test. e – h The DNAm at an age-associated region in PDE4C was analyzed by bisulfite amplicon sequencing (BA-seq). The heatmaps exemplify the presence of methylated (red) and non-methylated (blue) CpGs within the PDE4C amplicon, covering 26 neighboring CpGs. The age-associated CpG of the aging signature is indicated by arrow. Exemplary heatmaps are depicted for e) a healthy donor, and f) a PMF patient blood sample of the same age. The frequency of reads is clustered according to their DNAm patterns. The same analysis was performed in colony-forming units (CFUs) on day 14 that were either g) a wild type (WT), or h) harbored the JAK2 V617F mutation. Unlike the blood samples from PMF patients or controls, the CFUs exhibited a distinct DNAm pattern that appears to reflect the clonal characteristics of the colony-initiating cells
Article Snippet: We employed a clinically validated amplicon-based next-generation sequencing (
Techniques: Amplification, Sequencing, Methylation, Mutagenesis